A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

A superconducting transition temperature as high as 100 K was recently discovered in one monolayer FeSe grown on SrTiO3. The discovery ignited efforts to identify the mechanism for the markedly enhanced Tc from its bulk value of 8 K. There are two main views about the origin of the Tc enhancement: interfacial effects and/or excess electrons with strong electron correlation. Here, we report the observation of superconductivity below 20 K in surface electron-doped bulk FeSe. The doped surface layer possesses all (...) the key spectroscopic aspects of the monolayer FeSe on SrTiO3. Without interfacial effects, the surface layer state has a moderate Tc of 20 K with a smaller gap opening of 4.2 meV. Our results show that excess electrons with strong correlation cannot induce the maximum Tc, which in turn reveals the need for interfacial effects to achieve the highest Tc in one monolayer FeSe on SrTiO3. (shrink)

In diffusion creep, the contribution of grain-boundary sliding to the overall strain o s can be evaluated in arbitrary polycrystals, if the angular distribution of grain boundaries is known. A o s value of 0.5 is obtained for two-dimensional equiaxed microstructures consisting of regular hexagonal grains, equiaxed grains grown from a Voronoi structure or grains having a circular distribution of grain-boundary angles. The o s value is also evaluated for uniaxially deformed 2D microstructures, both diffusionally and uniformly deformed. For the (...) former, the deformed microstructure is obtained by the simulation of microstructural evolution in polycrystals with straight grain boundaries. The o s value increases gradually with increasing or decreasing strain and is larger in the diffusionally deformed microstructures than in the uniformly deformed microstructures for a given grain aspect ratio. The o s value for three-dimensional polycrystalline microstructures is also obtained from an ellipsoidal distribution of grain-boundary angles. The resultant o s value is 0.60 for 3D equiaxed polycrystals and increases gradually with increasing strain. (shrink)

Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

Ḍırār b. ʿAmr ve ʿAbdullāh b. Yezīd el-Fezārī, dönemlerinin önde gelen kelâmcıları arası yer almışlardır. Onlara dair bilgilerimiz çok uzun bir süre sadece makâlât ve tarih kitaplarındaki anlatımlara dayanıyordu. Yakın tarihimizde bu eksikliği gideren gelişmeler oldu. Ḍırār’ın günümüze intikal eden ilk ve tek eseri olan Kitābu’t-Taḥrīş, 2014 yılında neşredildi. Bu eser, doğrudan kelâm alanıyla ilgili olmasa da mezheplerin dağılımı ve fikirleri hakkında bilgiler ihtiva eden en eski Muʿtezilî kaynaklar arasında yer almaktadır. Ḍırār bu kitabında farklı dinî grupların rivâyetleri birbirlerine karşı (...) nasıl kullanıp suistimal ettiklerini konu edinmiştir. Eserin özelliği sadece ihtiva ettiği rivâyetlerde değil, meseleyi ele alış ve anlatım tarzında da bulunuyor. Ḍırār bu çalışmasıyla sonraki nesilleri birçok yönden etkilemiştir. ʿAbdullāh b. Yezīd el-Fezārī, eserlerinin günümüze ulaşması bakımından daha şanslıdır. Bir proje kapsamında 2014 yılından itibaren onun tam on bir eseri yayımlanmıştır. Bunlar arasında kelâm ilmine hasredilmiş birçok neşir yer almaktadır. Böylece çağdaş İslâm araştırmacıları ʿAbdullāh’ın fikirlerini az sayıdaki makâlât referanslarından bağımsız olarak doğrudan kendi kaleminden öğrenme imkanı elde etmiş oldular. Bunun ötesinde bu çalışmalar erken dönem kelâm ilminin en eski kaynakları arasına girmiştir. Bu yayımlar arasında özellikle Kitābu’r-Rudūd dikkat çekmektedir. Sebebi ise Kitābu’t-Taḥrīş ile olan benzerliğinden dolayıdır. Neredeyse her iki kitabın tamamı birbirinin aynısıdır ve karşılıklı atıflar içermemektedirler. Bu tür bir yazım faaliyeti günümüzde tereddütsüz intihal olarak adlandırılırdı. İki mütekellim arasında kronolojik farklar olmadığından kimin kimden etkilendiğini söylemek ilk aşamada zordur. Ḍırār ve ʿAbdullāh’ın birbirlerinden haberdar oldukları anlaşılıyor: İkisi de Kûfe’de yaşamış, Abbâsî halifesi Hārūn er-Reşīd döneminde (786-809) Bağdat’a geçmişler ve orada Hişām b. el-Ḥakem’le (ö. 179/795) imâmete dair Yaḥyā b. Ḫālid el-Bermekī’nin (ö. 190/805) rehberlik ettiği aynı münazara ortamında bulunmuşlardır. Eserlerin özgünlüğü ve etkisi hasebiyle bu çağdaş hemşehrilerden kimin kime kaynaklık etmiş olabileceği sorusu merak uyandırıyor. İkisinin de hem rivâyetleri merkeze alan bir eser vermek için hem bu tür bir telifin fikir babası olmasına delalet eden gerekçeleri var. Bu makalede, öncelikle ikisinin biyografik benzerlikleri takdim edilmiş, akabinde iki eser arasında mukayeselere yer verilmiştir. Kıyaslama, eserlerin hayat öyküleriyle uyumlulukları ve eserlerin tertip ve düzeni üzerinden yapılmıştır. Yöntem olarak aralarındaki paralelliklerden çok farklılıklara odaklanılmıştır. Son olarak ikisinin dayandığı ortak bir kaynağın varlığı sorgulanmıştır. Bu emârelerden hareketle kimin kime öncülük etmiş olabileceğine açıklık getirilmek amaçlanmıştır. (shrink)

We study the notion of weak canonical bases in an NSOP $_{1}$ theory T with existence. Given $p=\operatorname {tp}$ where $B=\operatorname {acl}$ in ${\mathcal M}^{\operatorname {eq}}\models T^{\operatorname {eq}}$, the weak canonical base of p is the smallest algebraically closed subset of B over which p does not Kim-fork. With this aim we firstly show that the transitive closure $\approx $ of collinearity of an indiscernible sequence is type-definable. Secondly, we prove that given a total $\mathop {\smile \hskip -0.9em ^| \ (...) }^K$ -Morley sequence I in p, the weak canonical base of $\operatorname {tp}$ is $\operatorname {acl}$, if the hyperimaginary $I/\approx $ is eliminable to e, a sequence of imaginaries. We also supply a couple of criteria for when the weak canonical base of p exists. In particular the weak canonical base of p is the intersection of the weak canonical bases of all total $\mathop {\smile \hskip -0.9em ^| \ }^K$ -Morley sequences in p over B. However, while we investigate some examples, we point out that given two weak canonical bases of total $\mathop {\smile \hskip -0.9em ^| \ }^K$ -Morley sequences in p need not be interalgebraic, contrary to the case of simple theories. Lastly we suggest an independence relation relying on weak canonical bases, when T has those. The relation, satisfying transitivity and base monotonicity, might be useful in further studies on NSOP $_1$ theories. (shrink)

This Festschrift seeks to honor three highly distinguished scholars in the Department of Philosophy, University of Michigan: William K. Frankena, Charles L. Stevenson, and Richard B. Brandt. Each has made significant con­tributions to the philosophic literature, particularly in the field of ethics. Michigan has been fortunate in having three such original and productive moral philosophers serving on its faculty simultaneously. Yet they stand in a long tradition of excellence, both within the Department and in the University. Let us trace that (...) tradition briefly. The University of Michigan opened in 184l. lts Department of Literature, Science, and the Arts at first resembled a typical American college of that period, with religious and ethical indoctrination playing a central role in course offerings. But when Henry Tappan, a Presbyterian clergyman and Professor of philosophy, became President in 1852, he succeeded in shifting the emphasis from indoctrination to inquiry and scholarship. Though he was dismissed for his policies in 1863, Tappan's efforts to establish a broad and liberal curriculum prevailed. Michigan was to take its place among the leading educational institutions in this country, and to achieve an international reputation as a research center. Several past philosophers are worthy of mention here. George Sylvester Morris, an absolute idealist, joined the Department in 1881, having served from 1870 as Chairman of the Department of Modern Languages and Literature. He assumed the Chairmanship of Philosophy in 1884. (shrink)

This volume brings together flux essays by an eminent scholar on the origins, development, and import of Kant's philosophy, chiefly in its metaphysical aspects. Four of these were separately published between 1924 and 1926, but until now have been difficult to obtain, despite great demand. Their appearance here will be welcomed. The thesis emerging from these studies is that the critical philosophy originates in metaphysical probings concerning the nature and presuppositions of being, and issues in doctrines which, despite psychological, epistemological, (...) and ethical presentation, are intended to have definite ontological import. --L. K. B. (shrink)

There is a great deal of interest in the relation between the status of women and fertility—by humanists, academics and policy-makers concerned with bringing about fertility declines. The three aspects of women's status most frequently linked to fertility are their education, employment and type of husband-wife interaction. Research to date has not given us a clear and consistent explanation of these relationships and has not confirmed causality. The effects of these three factors on fertility vary considerably across national boundaries and (...) even within different sectors of the same society. Some of the assumptions held by both researchers and policymakers must be re-thought in the interests of more useful future research and of sounder policy. (shrink)

A time-symmetric formulation of nonrelativistic quantum mechanics is developed by applying two consecutive boundary conditions onto solutions of a time- symmetrized wave equation. From known probabilities in ordinary quantum mechanics, a time-symmetric parameter P0 is then derived that properly weights the likelihood of any complete sequence of measurement outcomes on a quantum system. The results appear to match standard quantum mechanics, but do so without requiring a time-asymmetric collapse of the wavefunction upon measurement, thereby realigning quantum mechanics with an important (...) fundamental symmetry. (shrink)

Stone, J. Thoughts on supposed "Death of law".--Krishna Iyer, V. R. Jurisprudence and jurisconscience.--Sharma, G. S. Law and social change in India.--Sharma, S. D. The concept of justice in Manu.--Chand, H. Legal values for a developing country.--Ramarao, T. S. The new international law relating to the rights and duties of States.--Sinha, B. S. Custom and customary law in Indian jurisprudence.--Mazumdar, D. L. Techno-economic structure of our industrial society.--Subrahamanian, N. Law and social change.

The covariant Klein-Gordon equation requires twice the boundary conditions of the Schrödinger equation and does not have an accepted single-particle interpretation. Instead of interpreting its solution as a probability wave determined by an initial boundary condition, this paper considers the possibility that the solutions are determined by both an initial and a final boundary condition. By constructing an invariant joint probability distribution from the size of the solution space, it is shown that the usual measurement probabilities can nearly be recovered (...) in the non-relativistic limit, provided that neither boundary constrains the energy to a precision near ℏ/t 0 (where t 0 is the time duration between the boundary conditions). Otherwise, deviations from standard quantum mechanics are predicted. (shrink)

Provider claims to conscientious objection have generated a great deal of heated debate in recent years. However, the conflicts that arise when providers make claims to the "conscience" are only a subset of the more fundamental challenges that arise in health care practice when patients and providers come into conflict. In this piece, the author provides an account of patient-provider conflict from within the moral tradition of St. Thomas Aquinas. He argues that the practice of health care providers should be (...) understood as a form of practical reasoning and that this practical reasoning must necessarily incorporate both "moral" and "professional" commitments. In order to understand how the practical reasoning of provider should account for the needs and commitments of the patient and vice versa, he explores the account of dependence provided by Alasdair MacIntyre in his book Dependent Rational Animals. MacIntyre argues that St. Thomas’ account of practical reasoning should be extended and adapted to account for the embodied vulnerability of all humans. In light of this insight, providers must view patients not only as the subjects of their moral reflection but also as fellow humans upon whom the provider depends for feedback on the effectiveness and relevance of her practical reasoning. The author argues that this account precludes responsive providers from adopting either moral or professional conclusions on the appropriateness of interventions outside the individual circumstances that arise in particular situations. The adoption of this orientation toward patients will neither eradicate provider-patient conflict nor compel providers to perform interventions to which they object. But this account does require that providers attend meaningfully to the suffering of patients and seek feedback on whether their intervention has effectively addressed that suffering. (shrink)

Pickering & Garrod (P&G) suggest that communicators synchronize their processing at a number of linguistic levels. Whereas their explanation suggests that representations are being compared across individuals, there must be some representation of all conversation participants in each participant's head. At the level of the situation model, it is important to maintain separate representations for each participant. At other levels, it seems less crucial to have a separate representation for each participant. This analysis suggests that different mechanisms may synchronize representations (...) at different linguistic levels. (shrink)

A sympathetic exposition, carefully documented, of the meaning and function of aesthetic concepts in the Enneads. The Plotinian dialectic is compared to the artistic process. Aesthetic experience is found analogous to the mystical, and artistic intuition similar to ecstasy.--L.K.B.

Mind uploading speculation and debate often concludes that a procedure described as gradual in-place replacement preserves personal identity while a procedure described as destructive scan-and-copy produces some other identity in the target substrate such that personal identity is lost along with the biological brain. This paper demonstrates a chain of reasoning that establishes metaphysical equivalence between these two methods in terms of preserving personal identity.

A collection of six unrelated articles by as many authors. First come three scholarly studies, dealing with causality in Aristotle, St. Augustine's metaphysics of created being, and St. Thomas as a commentator on Aristotle. The fourth is an exposition of Hegel's views on scepticism. Next comes a reconstruction, within the scholastic spirit, of "classical formal logic." The concluding and most interesting article is a bibliographical survey of recent works in the history of ancient philosophies. --L. K. B.

A collection of essays on various aspects of philosophy of science, written around the turn of the century by a perceptive historian of science and methodologist who, under the influence of Peirce, Mach and Peano, anticipated many basic doctrines of the later semantically oriented analytic philosophy. The short introduction discusses Vailati's viewpoint in connection with his chief contemporaries; a brief biography and bibliography are provided. --L. K. B.

Five previously published articles dealing with various topics in philosophy of history. They center on the problem of a metaphysics adequate to a radical emphasis on history over against nature and to a conception of values as emergent through history.--L. K. B.

Although it deals with the important problem of the metaphysical implications of linguistic structure and the basis for selection of a cognitive language, and contains some interesting theses, this book is made almost useless by its imprecise and unclear argumentation and awkward style.--L. K. B.

This presentation of scientific methodology tries to avoid metaphysical issues without being unphilosophical. Drawing from a wide range of material, the book describes clearly but rather generally what empirical scientists are concerned with, how they proceed, what they accomplish. The five parts deal with the roles in science of definitions, physical laws and theories, induction, and the interplay of reason and immediate experience. Despite the slant indicated by the many quotations from St. Thomas and Aristotle--peculiarly but pleasantly combined with passages (...) from Einstein, Schrödinger, de Broglie, Eddington, etc.--a rather objective presentation is achieved.--L. K. B. (shrink)

A meticulous examination of the logical and axiological principles of analogical inference in legal reasoning. The first part presents an elementary but useful survey of traditional and modern logical analyses of analogy and analogical inference. In the second part, these concepts are examined in their juridical applications. Much is made of the conclusion that analogical inference cannot be rendered "binding" by logical considerations alone; to make up for this in legal reasoning, axiological principles must be employed.--L. K. B.

A dry record, without argument, of conclusions reached on a wide variety of topics through fifty years of scholastic philosophizing.--L. K. B.

An over-compact but vivid metaphysical scheme woven out of categories such as process, endurance, self-realization, etc., and stressing a contrast between "cosmic" reality, a perpetual activity whose unity lies in the urge for endurance of which it is the self-realization, and "anthropocosmic" reality, a perishing complex of realized finite purposes. The vocabulary and style are obscure, and originality is more is evidence than fruitfulness.--L. K. B.

A "biblico-theological" study of certain aspects of the scripturally revealed will of God for man's conduct, aiming "to show the basic unity and continuity of the biblical ethic." --L. K. B.